The Commission may prescribe, and from time to time amend, regulations governing⁠—

(1)  the operation of the Panama Canal;

(2)  the navigation of the harbors and other waters of the Panama Canal and areas adjacent thereto, including the ports of Balboa and Cristobal;

(3)  the passage and control of vessels through the Panama Canal or any part thereof, including the locks and approaches thereto;

(4)  pilotage in the Panama Canal or the approaches thereto through the adjacent waters; and

(5)  the licensing of officers or other operators of vessels navigating the waters of the Panama Canal and areas adjacent thereto, including the ports of Balboa and Cristobal.